Dr Hamish Lemmey
College Lecturer in Medicine (Pharmacology)
I am currently reading for Graduate-Entry Medicine at Magdalen College, University of Oxford. I hold a BSc (Hons) from the University of Queensland and a DPhil in Cardiovascular Science from the University of Oxford, which was supported by a British Heart Foundation 4-Year Studentship.
Undergraduate teaching
I tutor first year medical students for Physiology and Pharmacology and third year medical and biomedical sciences students for Vascular Biology.
-
Research interests
The vasoconstriction and vasodilation of small resistance arteries is incredibly important for the maintenance of blood pressure and supply. In cardiovascular diseases, such as diabetes mellitus and hypertension, the function of these arteries is compromised contributing to the onset and severity of the condition. However, the heterocellular signalling pathways that underpin their function and why they are disrupted have not been fully elucidated. I hope to address these gaps in our knowledge through my research and improve our understanding of these widespread diseases to identify novel ways to treat them.
-
Publications
- Phospholemman phosphorylation regulates vascular tone, blood pressure, and hypertension in mice and humans Boguslavskyi, A., Tokar, S., Prysyazhna, O., Rudyk, O., Sanchez-Tatay, D., Lemmey, H.A.L., Dora, K.A., Garland, C.J., Warren, H.R., Doney, A., Palmer, C.N.A., Caulfield, M.J., Walker, J.V., Howie, J., Fuller, W., Shattock, M.J. (2021). Circulation, 143(11), 1123-1138.
- Endothelial nitric oxide suppresses action-potential-like transient spikes and vasospasm in small resistance arteries Smith, J.F., Lemmey, H.A.L., Borysova, L., Hiley, C.R., Dora, K.A., Garland, C.J. (2020). Hypertension, 76(3), 785-794.
- Intrinsic regulation of microvascular tone by myoendothelial feedback circuits Lemmey, H.A.L., Garland, C.J., & Dora, K.A. (2020) in Jackson, W.F. (ed.) Ion Channels and Calcium Signaling in the Microcirculation. Cambridge, MA: Academic Press, 327-355.
- Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice Lemmey, H. A. L., Ye, X., Ding, H. C., Triggle, C. R., Garland, C. J., & Dora, K. A. (2018). Vascular Pharmacology, 103-105, 29-35.
- Vasorelaxation to the nitroxyl donor isopropylamine NONOate in resistance arteries does not require perivascular calcitonin gene–related peptide Pinkney, A., Lemmey, H. A. L., Dora, K. A., & Garland, C. J. (2017). Hypertension, 70(3), 587-593.
- Voltage- dependent Ca2+ entry into smooth muscle during contraction promotes endothelium-mediated feedback vasodilation in arterioles Garland, C. J., Bagher, P., Powell, C., Ye, X., Lemmey, H. A. L., Borysova, L., & Dora, K. A. (2017). Science Signaling, 10(486).