Dr Sujata Biswas
Senior Research Fellow in Medicine
Sujata graduated from Cambridge Medical School in 2007 and undertook Core Medical and Gastroenterology training in the Oxford deanery. She was a graduate student at Hertford College from 2014 to 2017 for her DPhil, funded by the MRC. This was on GI cancer stem cell biology in the laboratory of Simon Leedham at the Wellcome Centre for Human Genetics in Oxford. She was appointed as a Consultant Gastroenterologist in Buckinghamshire and Oxfordshire trusts in 2019. She has an interest in therapeutic colonoscopy and is a bowel cancer screening accredited endoscopist. She has been teaching Clinical Medicine at Hertford since 2015 and now coordinates clinical teaching. Sujata’s research interest is in familial colorectal polyposis syndromes. A selection of recently published research is below.
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Publications
Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis. Palles C, Freeman-Mills L, Arbe-Barnes E, Feeley N, Chegwidden L, Curley H, Galavotti S, Woolley C, Cheadle J, Mouradov D, Sieber O, Salatino S, Thorn S, Goel A, Fernandez-Tajes J, Omwenga S, Biswas S, Maughan T, Leedham SJ; S:CORT Consortium; UK Colorectal Cancer Genomics Consortium; CORGI Consortium; WGS500 Consortium; Koelzer VH, Wang LM, Arnold R, East JE, Tomlinson I.Gut. 2025 Dec 24:gutjnl-2025-337030. doi: 10.1136/gutjnl-2025-337030.
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA. Murphy L, Inchauspé J, Valenzano G, Holland P, Sousos N, Belnoue-Davis HL, Li R, Jooss NJ, Benlabiod C, Murphy E, Etzioni Z, Shepherd E, Denly L, Biswas S, Chen L, O’Sullivan J, Rimmer MP, Khan AO, Karali CS, Nasreddin N, Hitchcock IS, Koupenova M, Kriaucionis S, Hughes JR, O’Neill E, Vatish M, Rees P, Leedham S, Desborough M, Mead AJ, Schuster-Böckler B, Gregory CD, Psaila B.Science. 2025 Aug 14;389(6761):eadp3971. doi: 10.1126/science.adp3971. Epub 2025 Aug 14.
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling. Mulholland EJ, Belnoue-Davis HL, Valbuena GN, Gunduz N, Ligeza A, Lin M, Biswas S, Gil Vasquez E, Omwenga S, Nasreddin N, Hodder MC, Wang LM, Ng AS, Jennings E, Midwood KS, Dedi N, Irshad S, Ridgway RA, Phesse TJ, East J, Tomlinson IP, Davies GC, Sansom OJ, Leedham SJ.Nat Commun. 2025 Jun 4;16(1):5167. doi: 10.1038/s41467-025-60364-6.
Germline variant testing in serrated polyposis syndrome. Murphy A, Solomons J, Risby P, Gabriel J, Bedenham T, Johnson M, Atkinson N, Bailey AA, Bird-Lieberman E, Leedham SJ, East JE, Biswas S.J Gastroenterol Hepatol. 2022 May;37(5):861-869. doi: 10.1111/jgh.15791. Epub 2022 Feb 18.